Similarly, the proportion of samples with strongly positive Tiam1 expression was 42.5 % (65/153) in breast cancer and40.3 % (27/67) in DCIS, which were significantly higher than that of adjacent non-tumor tissues (12.7 %, 8/63) (P < 0.01, respectively) (Table 1). This evidence concerns the gene TIAM1 and breast cancer.