Importantly, high Tiam1 expression also emerged as a significant independent prognostic factor for DFS (HR: 1.470, 95 % CI: 1.056–2.047, P = 0.022) and 10-year OS (HR: 1.549, 95 % CI: 1.112–2.157, P = 0.010) in patients with breast cancer (Table 3). The gene discussed is TIAM1; the disease is breast carcinoma.