Interestingly, the Hallmark analysis results included novel as well as already described common dysregulated pathways related with insulin resistance and atherosclerosis such as inflammatory response, IL6 JAK STAT3 signaling, TNFA signaling via NFKB, interferon gamma response, fatty acid metabolism, oxidative phosphorylation and adipogenesis (Table 1). The gene discussed is STAT3; the disease is Insulin resistance.