DM is associated with presence of specific autoantibodies which are usually divided into myositis specific autoantibodies (including anti-Mi-2, anti-CADM-140, anti-SAE, anti-p155/140 (anti-TIF-1γ), anti-MJ, anti-t-RNA synthetase, and anti-PMS1 antibodies) and myositis associated autoantibodies (including anti-Ro/SSA, anti-U1RNP, anti PM/Scl, and Anti-Ku antibodies) [4]. The gene discussed is PMS1; the disease is myositis disease.