For instance, the transcription factor hepatocyte nuclear factor 1-beta (HNF1B), often over-expressed in clear cell ovarian cancer (CCC)22 showed the strongest expression in the CCC OVISE cell line and the IGROV1 cell line, which, according to its genomic profile, may be of clear cell or endometrioid origin9. This evidence concerns the gene HNF1B and ovarian clear cell cancer.