Our results suggested major increases in Nrf-2 and HO-1 levels and decreases in NF-κB and MDA levels of the various reproductive tissue parts and serum when administered with Tribulus terrestris similarly to a study which the extract was restored antioxidant enzyme activity and their expression profile in kidney tissue [50] and another study that extract blocked proliferation and induced apoptosis in cancer cells through the inhibition of NF-κB signaling [51]. This evidence concerns the gene NFKB1 and cancer.