Heme oxygenase (HO) pathway has a major role in male reproductive system and sexual dysfunctions and heat shock protein 32 or heme oxygenase-1 protein (HO-1) is known to be an inducible isoform protein and it is induced by many different conditions and agents including hypoxia, cytokines, oxidative stress, heat shock, and reactive oxygen species [28, 29]. Here, HMOX1 is linked to sexual dysfunction.