For example, studies in mice displaying a nonphosphorylatable Ser51Ala mutant eIF2α in intestinal epithelial cells (IECs) revealed that eIF2α phosphorylation is essential for proper Paneth cell function, and mutant mice displayed increased susceptibility to oral Salmonella infection and dextran sulfate sodium (DSS)-induced colitis [2]. The gene discussed is EIF2A; the disease is Salmonella Infections.