Therefore, in contrast to the suggestion by Zhang et al. 16 that CYLD deficiency in macrophages was responsible for the increased AOM/DSS-induced colon carcinogenesis in Cyld−/− mice to AOM/DSS-induced colon cancer, loss of CYLD catalytic activity specifically in myeloid cells did not sensitize mice to AOM/DSS-induced inflammation and tumour development. Here, CYLD is linked to infectious otitis media.