We found that neither Ripk3−/− nor double FADDIEC-KO/Ripk3−/− mice, which lack RIPK3 in all cells and FADD specifically in IECs15, showed increased susceptibility to AOM/DSS- or AOM-mediated intestinal tumorigenesis (Supplementary Fig. 2). The gene discussed is RIPK3; the disease is infectious otitis media.