In addition, CYLDΔ932IEC Superp53 mice developed less AOM/DSS- and AOM-induced colon tumours compared with CYLDΔ932IEC littermates, showing that increased p53 expression could partially restore the increased susceptibility of CYLDΔ932IEC mice to chemical carcinogen-induced colon tumorigenesis (Fig. 4d,e). The gene discussed is TP53; the disease is colonic neoplasm.