BUB1B and cataract: Baker et al. found that decreased BubR1 expression induces cellular senescence through p16INK4a up-regulation, and that mutant mice with decreased BubR1 expression display various progeroid phenotypes, such as short lifespan, cachectic dwarfism, lordokyphosis, cataracts, loss of subcutaneous fat and impaired wound healing3, 4, 5, 6.