Protein tyrosine phosphatase (PTP) expressed in insulin-sensitive tissues (such as liver, muscle, and adipose tissue) has a key role in the regulation of insulin signaling and pathway activation [9], making PTP a promising target for the treatment of type 2 diabetes mellitus (T2DM) and obesity [10]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.