Notably, as in C57BL/6 mice, IFN-γ-R−/− mice infected with the sncRNA ko displayed a significantly higher viral genomic load when compared to infection with parental virus or sncRNA ko-revertant (P = 0.011 for parental virus versus sncRNA ko, and P = 0.002 for sncRNA ko versus sncRNA ko-revertant; Mann-Whitney Rank Sum Test) (Fig. 9). This evidence concerns the gene IFNGR1 and infection.