In the same vein, Nowaczyk etal. (2014) reported seven patients with deletions of chromosome19p13.3 including the MAP2K2 gene (OMIM *601263) and phenotype featuresof Cardio-facio-cutaneous syndrome, which is a RASopathy known to be caused byactivating mutations of the BRAF, MAP2K1,MAP2K2, or KRAS genes. This evidence concerns the gene BRAF and cardiofaciocutaneous syndrome.