Using this approach, it was found that gene transcripts involved in cellmigration are significantly down-regulated in a variety of FD patient-derived cells,including fibroblasts (Close et al.,2006), induced pluripotent stem cells (iPSCs, Lee et al., 2009), and olfactory ectomesenchymalstem cells (hOE-MSCs, Boone et al.,2010), as well as in IKBKAP siRNA- transfected cell linesincluding HeLa (Close et al.,2006), and SHSY5Y neuroblastoma cells (Cohen-Kupiec et al., 2011). This evidence concerns the gene ELP1 and Fabry disease.