PPARG and obesity due to melanocortin 4 receptor deficiency: PPARG is activated by lipophilic hormones, fatty acidsfrom the diet, and their metabolites (He, 2009).The Ala allele of the polymorphism Pro12Ala of PPARG was associatedwith obesity in a population from Spain (OR = 2.36, p = 0.03) and from India (OR = 3.2,p = 0.02) (González-Sánchez et al.,2002; Bhatt et al.,2012), while the Pro allele was a risk factor for type 2 diabetes in a Frenchpopulation (OR = 1.37, p = 0.04) (Ghoussaini etal., 2005).