Thepolymorphisms evaluated in this study are associated with obesity in Afro-Americans(Bostrom et al., 2008) andwith increased BMI, waist circumference, fasting insulin levels and skin fold thicknessin Mexicans living in USA (Richardson etal., 2006; Sutton etal., 2005). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.