CD40LG and dengue disease: The seropositive infants had a significantly lower E protein-specific but not total ASC IgM/IgG ratio (Fig 4C), and the percentage of dengue-specific ASC in the total IgG ASC of the seropositive and seronegative infants was 69% (31–96) and 6% (1.4–12), respectively (P = 0.003, Mann-Whitney test) (Fig 4D).