These results are in accordance with previously obtained results applying olmesartan in 5/6 nephrectomy which was effective in reducing systemic oxidative stress [25], as well as with finding that tempol alone attenuated systemic oxidative stress in the model of L-NAME induced hypertension [26], while tempol alone or tempol plus enalapril significantly attenuated plasma oxidative stress in AngII-induced hypertensive rats [27]. Here, AGT is linked to hypertensive disorder.