The present study has shown that chronic single treatments with SOD mimetic, tempol and AT1R blocker, losartan or their combination significantly enhanced plasma antioxidant capacity and erythrocyte antioxidant enzyme activities, thus reduced plasma lipid peroxidation, leading to the improvement of systemic oxidative status in SHR with the early course of ADR-induced nephropathy. This evidence concerns the gene AGTR1 and Nephropathy.