EGFR and neoplasm: Although it is known that the α1,2-fucosylated LeY antigens can promote cell proliferation and tumorigenesis by activating EGFR/MAPK signaling,52, 53 our finding may offer yet another pathway in which α1,2-fucosylated LAMP-1 and 2 may regulate autophagy biogenesis, thereby influencing tumor development and progression.