In general, FUT1 preferentially generates H type 2 antigens, whereas FUT2 shows preference for H type 1.3 The H antigens can be further substituted by adding a fucose onto the N-acetylglucosamine of type 1 or type 2 precursors in α1,4- or α1,3-linkage, giving rise to Lewis B (LeB) and Lewis Y (LeY) antigens, respectively.4 The aberrant α1,2-fucosylation is a hallmark of multiple types of cancers. This evidence concerns the gene FUT1 and cancer.