TFAP2B encodes AP-2ß, a key transcription factor for craniofacial development, and heterozygous missense mutations in TFAP2B cause Char Syndrome, which includes dysmorphic facial features such as hypertelorism, downward slanting palpebral fissures, flattened and broad nose, short philtrum, and triangular mouth with prominent upper lips [16, 17]. This evidence concerns the gene TFAP2B and Char syndrome.