SOD1 and Creutzfeldt Jacob disease: The unexpected reduction of MD, detected with all the three protocols, could be explained by the vacuolization phenomena observed in G93A-SOD1 motor neuron by our histology and TEM as well as in previous studies [66]; indeed vacuolization is associated with diffusivity reduction in other neurodegenerative pathologies such as Creutzfeldt-Jakob disease [67,68].