Among the genes within 250kb of the peak signal are two potentially relevant candidate genes, GNAI3 and ALX3. Mutations in GNAI3, which encodes a G protein subunit involved in pharyngeal arch patterning, cause auriculocondylar syndrome, a rare craniofacial disorder [36,37], although hyper- or hypotelorism have not specifically been described. The gene discussed is ALX3; the disease is auriculocondylar syndrome.