Interestingly, several variants causing changes adjacent to residue 1328 have been identified in patients with type 3 long-QT syndrome (LQT3) [15–19] and among those variants E1295K and A1330P showed similar biophysical modifications of the Nav1.5 as V1328M (i. e., increase in window currents) [15, 18]. Here, SCN5A is linked to long QT syndrome 3.