The most highly affected pathways in PE include: Wnt signaling pathway; Long-term potentiation; Melanoma; TGF-beta signaling pathway; T cell receptor signaling pathway; ErbB signaling pathway; mRNA surveillance pathway; PPAR signaling pathway; Ubiquitin mediated proteolysis; and Hedgehog signaling pathway (Table 6). This evidence concerns the gene TBXT and melanoma.