Indeed, IRX3 expression in adipocytes negatively correlated with obesity-related parameters of AT dysfunction, i.e. adipocyte diameter (Fig 2C) and AT inflammation as indicated by the number of infiltrating macrophages (Fig 2D) and CD68 mRNA expression in the SVF (Fig 2E). This evidence concerns the gene IRX3 and obesity due to melanocortin 4 receptor deficiency.