IFIH1 and systemic lupus erythematosus: Heritable mutations in RIG-I and MDA5 coding sequences have been identified as causative for Type 1 interferonopathies (inherited autoimmune disorders associated with an inborn elevated interferon response), including Aicardi–Goutières syndrome and systemic lupus erythematosus (SLE) in certain individuals as well as classic and atypical Singleton–Merten syndrome [194].