DHCR7 and tuberculosis: In line with this, a recent in vitro study reported that treatment of cells with cholesterol resulted in a 3-fold increase in vitamin D relative to cholesterol synthesis, demonstrating that cholesterol feeds back via 7-dehydrocholesterol reductase (DHCR7) increasing vitamin D production.[46] Indeed our results indicate that rifampicin-based anti-TB therapy alone significantly increased the plasma cholesterol level (Fig. 2).