Interaction of TH status and sex was found for TT4 and fT4 under hyperthyroidism (TT4: F(1,28) = 21.26, p < 0.0001; fT4: F(1,28) = 10.75, p = 0.0028) but not under hypothyroidism (TT4: F(1,28) = 0.1272, p = 0.7241; fT4: F(1,28) = 0.2350, p = 0.6316) and not for fT3 (hyperthyroid: F(1,28) = 3.658, p = 0.0661; hypothyroid:F(1,28) = 0.8460, p = 0.3656). The gene discussed is TH; the disease is hyperthyroidism.