INS and colorectal carcinoma: Additionally, IGF1, insulin, leptin, TG, adiponectin, PPARγ, IGF1R, and IGFBP3 investigated in the current study have all been implicated in colorectal carcinogenesis and have been proposed as CRC risk markers21, 25, 27, 28, 29, 47, 80, 81, 82, 83.