Additionally, IGF1, insulin, leptin, TG, adiponectin, PPARγ, IGF1R, and IGFBP3 investigated in the current study have all been implicated in colorectal carcinogenesis and have been proposed as CRC risk markers21, 25, 27, 28, 29, 47, 80, 81, 82, 83. This evidence concerns the gene IGFBP3 and colorectal carcinoma.