On the other hand, elevated levels of specific circulating miRNAs (including some of those mentioned above) significantly associated with increased levels of insulin resistance (i. e., higher HOMA-IR and lower QUICKI) and insulin secretion (i. e., higher HOMA-B) in people from the Healthy and Prediabetes groups (Fig. 6A–C,E,H, Supplementary Tables 9 and 10). This evidence concerns the gene INS and prediabetes syndrome.