Importantly, the contrary occurred in the T2D group (Supplementary Table 11), where higher levels of circulating miR-24, miR-34a, and miR-146a negatively correlated with c-peptide AUC (Fig. 7E), HOMA-B (indicator of β-cell activity/insulin secretion, Fig. 6L), and the insulinogenic index (ΔIns30/ΔGlu30, indicator of early-phase insulin secretion in response to glucose, Fig. 7F), respectively. The gene discussed is INS; the disease is type 2 diabetes mellitus.