The hypothesis is that chimpanzee adenovirus (ChAd) targeted by anti-CD40 camelid single-domain antibody (sdAb) containing a human tyrosinase (huTyr) cassette (a melanoma xeno-antigen) will cause maturation of myeloid DC, elaboration of the xeno-antigen payload, and an anti-tumor immune response. Here, TYR is linked to melanoma.