The mechanism by which netrin‐1 induces angiogenesis was proposed to involve the activation of its receptor deleted in colorectal cancer (DCC), which triggers the activation of extracellular signal‐regulated kinase (ERK)1/2, leading to an increase in the production of endothelial nitric oxide and the induction of endothelial cell migration and growth 30. The gene discussed is MAPK3; the disease is colorectal cancer.