Such self-propagating variants of fibrils assembled from covalently identical polypeptide chains are termed strains by the analogy to proliferation patterns of mammalian “prion strains” – distinct forms of PrP-amyloid-related Creutzfeldt-Jakob disease observed in individuals with expression of identical precursor PrPC protein14, 15, 16, 17, 18. Here, PRNP is linked to Creutzfeldt Jacob disease.