ERVW-1 and infection: This remodeling provides a trigger for T cell polarization and a focal point for the recruitment of MTOC-associated organelles that support cell-cell spread, including the Golgi compartment that resides proximal to the MTOC, thus potentiating delivery of intracellular Env to the plasma membrane (PM) to facilitate full VS formation and polarized virus assembly and budding for rapid infection of target cells by cell-cell spread.