Because the numbers of CD4+CD25+ T cells were reduced, which results in immune suppression, the activation of T-helper cells was enhanced, the expression of B-cell activating factor increased, and B-lymphocyte hyperthyroidism was induced to produce a variety of autoantibodies, which led to a series of immune system interaction disorders that resulted in multiple organ damage. The gene discussed is TNFSF13B; the disease is hyperthyroidism.