Liver failure is also observed in infection of the susceptible mouse strain DBA/2 [41], which is mirrored in BALB/c mice lacking expression of haemoxygenase-1 (HO-1, Hmox1−/−) [42], a free haem-catalyzing enzyme under the regulation of IL-10 that has been shown to be important in the pathogenesis of ECM and human CM [43, 44]. The gene discussed is IL10; the disease is liver failure.