F2 and hereditary thrombophilia due to congenital protein S deficiency: This potential relationship could be explained by alcohol’s adverse effect on host defense (defective neutrophil function and complement deficiency), clotting mechanism (defective prothrombin and vitamin K activity), bone metabolism (increased desorption, decreased formation), healing (vitamin B-complex and protein deficiency) and a direct toxic effect on periodontal tissues [16, 25, 26].