Both newly diagnosed and relapsed/refractory MM patient cells were sensitized by selinexor (P = 8.0 × 10−11 and P = 1.37 × 10−8, respectively) and KOS-2464 (P = 9.9 × 10−11 and P = 7.3 × 10−9, respectively) to doxorubicin (Fig. 2a, c) as shown by activated caspase 3 staining and detection by flow cytometry. Here, CASP3 is linked to Miyoshi myopathy.