Among the 30 phosphorylation sites of MARCKS, 16 sites were significantly altered compared to proteins from wild type mice with the same genetic background (B6/SJL); 9 of the 16 sites were hyperphosphorylated at 1 month of age before Aβ aggregation, and 4 of the 9 sites were also hyperphosphorylated in postmortem human brains of AD patients compared to non-neurological disease patients (Fig. 1a). The gene discussed is MARCKS; the disease is Alzheimer disease.