These unique relationships among pSer46-MARCKS, Aβ aggregation, and axon/dendrite markers suggest that pSer46-MARCKS phosphorylation may occur in degenerative neurites/regions of neuritic dystrophy surrounding the Aβ plaques, which are classical hallmarks of AD both in human and mouse model pathologies26, 27 and in impaired dendrites28. Here, MARCKS is linked to Alzheimer disease.