The staining of Eg5 (median H score, 299), RNF20 (median H score, 274), and RNF40 (median H score, 272) was much stronger in 99 breast carcinoma tissues than the staining of these proteins in 10 adjacent normal breast tissues (median H score,<20) (Fig. 7b). This evidence concerns the gene RNF40 and breast carcinoma.