So far seldom studies on the association between MBL2 polymorphisms and HCC risk were reported, only a study conducted in Italian population found no significant association between MBL2 genotypes and HCC risk6, however, the study has limited sample size, and it performed stratification according to both hepatitis B and C infection, which led to reduction in both sample size and statistical power. This evidence concerns the gene MBL2 and hepatocellular carcinoma.