MGMT and glioblastoma: Smith et al. reported a positive correlation of MGMT promoter methylation with survival in a prospective trial of 30 newly diagnosed GBM patients treated with Gliadel wafers and Gamma Knife radiosurgical boost followed by standard fractionated RT (60 Gy over 6 weeks) (but without TMZ, for the EORTC/NCIC data had not yet been published) [43].