Reports have shown that IL-8 has biological effects by binding to two chemokine receptors, CXCR1 (IL-8RA) and CXCR2 (IL-8RB), which are members of the seven transmembrane G-protein-coupled receptor (GPCR) family in human colorectal cancer [4]. This evidence concerns the gene CXCR2 and colorectal cancer.