In this context, aspirin may help in preventing colorectal cancer onset also in those conditions in which a hyperinsulinemic status (another pathological condition associated with an increased risk of developing colorectal cancer [60, 61],) with the activation of insulin and IGF-1 pathways [62, 63], may be per se responsible for the stimulation of rRNA transcription and p53 down-regulation [64]. The gene discussed is TP53; the disease is colorectal cancer.