In the present study of genetic variants of 132 genes (after removal of one pseudogene and six genes in chromosome X) in the Notch signaling pathway and NSCLC OS using the published GWAS datasets, we identified ADAM12 rs10794069 A > G, DTX1 rs1732793 G > A, TLE1 rs199731120 C > CA, TLE1 rs35970494 T > TC and E2F3 rs3806116 G > T as predictors of NSCLC OS. The gene discussed is ADAM12; the disease is non-small cell lung carcinoma.