FZD4 and ovarian carcinoma: High expression levels of NOTCH1 and NOTCH2 mRNA were found to be significantly associated with OS of ovarian cancer patients [16], and a 10-gene signature (FZD4, HES1, PSEN2, JAG2, PPARG, FOS, HEY1, CDC16, MFNG, and EP300) of the Notch pathway was identified to be associated with a high risk of recurrence of ovarian cancer [17].