HES1 and non-small cell lung carcinoma: For NSCLC, high expression levels of NOTCH1 and NOTCH3 have been found to be significantly associated with poor prognosis in lung adenocarcinoma [20, 21], whereas DLL4 and HES1 were also positively associated with poor OS of NSCLC patients [22], suggesting that Notch signal has biological significance and therapeutic application in NSCLC.