As shown in Table 1, we found that under an additive genetic model, ADAM12 rs10794069 G, DTX1 rs1732793 A, TLE1 rs199731120 CA, TLE1 rs35970494 TC and E2F3 rs3806116 T variant alleles were associated with a poor NSCLC OS, with a variant-allele attributed hazard ratio (HR) of 1.27 [95% Confidence interval (95% CI) = 1.13–1.42, P = 3.62E-05], 1.30 (95% CI = 1.14–1.49, P = 8.16E-05), 1.40 (95% CI = 1.16–1.68, P = 3.47E-04), 1.27 (95% CI = 1.11–1.44, P = 3.38E-04), and 1.21 (95% CI = 1.09–1.33, P = 2.56E-04), respectively. This evidence concerns the gene DTX1 and non-small cell lung carcinoma.