To better understand the mechanism by which CD73 modulates metastasis of HNSCC, we explored the effect of CD73 on Epithelial-Mesenchymal Transition (EMT), via the presence/absence of epithelial marker E-cadherin, N-cadherin, Vimentin, Twist, Snail and EMT transcriptional factor Slug. The gene discussed is NT5E; the disease is head and neck squamous cell carcinoma.