Similarly, we have demonstrated that exposure of the human CML cell line K562 to CM363 led to the induction of apoptosis as indicated by an increased annexin V binding as well as release of cytochrome c from the mitochondria into the cytoplasm, activation of caspases 3 and 9, and PARP cleavage. This evidence concerns the gene CASP3 and chronic myelogenous leukemia, BCR-ABL1 positive.