Actually the dominate role of SEPT 7 protein in controlling other septin family member expression have been discovered in Hela [34] with shRNA approach and Sept7 genetic depleted mouse fibroblast cells [35], our data further confirm those previous discoveries in breast cancer cell lines and additionally in primary human umbilical vein endothelial cell (Supplementary Figure 6B). The gene discussed is SEPTIN7; the disease is breast cancer.