High expression levels of four septins (SEPT2, 8, 9 and 11) were verified in paclitaxel (Taxol) resistant MDA-MB-231 cells [18], which suggests the possibility that septins can modulate microtubule-based breast cancer chemotherapy by their guidance towards microtubule and actin cytoskeleton dynamics, which have been quite well described in epithelial cells [19] and neuron cells [20]. The gene discussed is SEPTIN6; the disease is breast cancer.