Actually the dominate role of SEPT 7 protein in controlling other septin family member expression have been discovered in Hela [34] with shRNA approach and Sept7 genetic depleted mouse fibroblast cells [35], our data further confirm those previous discoveries in breast cancer cell lines and additionally in primary human umbilical vein endothelial cell (Supplementary Figure 6B). This evidence concerns the gene SEPTIN7 and breast carcinoma.