Amongst the 18 host markers that showed the most potential in the diagnosis of TB disease individually as determined by AUC, six (CRP, SAP, PCT, ferritin, TPA and SAA) were acute phase proteins, six (I-309, MIG, MIP-4, Apo A-1, transthyretin and CFH) were markers that play various roles in the body and have recently been identified as promising TB diagnostic candidates [16] [11], two (TNF-α and IP-10) are widely investigated TB biomarkers [17] whereas four (antithrombin III, GDF-15, NCAM, HCC1), were relatively new markers, which have not previously been investigated in the TB field. The gene discussed is NCAM1; the disease is tuberculosis.