The combination of NCAM with five other markers (SAP, IL-1β, sCD40L, IL-13 and Apo A-1), diagnosed TB disease regardless of HIV infection status, with high accuracy, whereas all the TB patients and individuals with ORD were accurately classified (100% sensitivity and specificity) when NCAM was used in combination with either A2M+IL-22+ferritin+myoglobulin+IL-12(p40), or A2M+IL-22+ferritin+TNF-β+MIP-4, in the absence of HIV infection. Here, CD40LG is linked to HIV infectious disease.