Indeed, the SLE T cells with JKAP downregulation (< 0.2 fold) displayed higher levels of phospho-Y394-Lck (SLE #6 and #10) than healthy T cells; however, Lck phosphorylation was also enhanced in the SLE T cells without JKAP downregulation (SLE #7 and #11) (Supplementary Figure S2A). Here, DUSP22 is linked to systemic lupus erythematosus.