DUSP22 and systemic lupus erythematosus: We found that JKAP protein levels were significantly reduced in purified peripheral blood T cells of human patients with SLE (JKAP/actin = 0.24 ± 0.05 fold) compared to those of healthy controls (JKAP/actin = 0.87 ± 0.26 fold) as determined by immunoblotting analyses (Figure 1A and 1B; P = 1.26×10-7).