Since the inflammatory microenvironment contribute to the tumorigenesis and the development of tumors, we speculate that the inhibition of TET2 activities, including non-enzymatic activity and enzymatic activity of TET2 protein, may occur in tumors such as gliomas, and then the repression of TET2's non-enzymatic activity results in the elevation of IL-6 level in cancers. Here, TET2 is linked to glioma.