In hematopoietic malignancies, including acute myeloid leukemias (AMLs), myeloproliferative neoplasms (MPN), myelodysplastic syndrome (MDS), and chronic myelomonocytic leukemia (CMML), TET2 gene has been shown to be frequently mutated [75–86]. Here, TET2 is linked to chronic myelomonocytic leukemia.