Other inhibitors of prostate cancer cells, such as the plant lignin deoxy-podophyllotoxin (DPT, ref [24]), vitamin D receptor agonist EB1089 and liver X receptor agonist T090198, did not significantly reduce P-RPS in PC-3 and C4-2B cells (Supplementary Figures S2-A, -B). The gene discussed is VDR; the disease is prostate cancer.