Ser-81 is the most abundantly phosphorylated amino acid among various androgen-induced serine phosphorylation sites of AR [44], and phospho-AR(Ser-81) can promote prostate cancer cell growth and enhance AR's stability, chromatin binding and transcriptional activity – all indicating an important role for this phospho modification in human prostate cancer [45–48]. The gene discussed is AR; the disease is prostate cancer.