As overexpression of PLK1 provides an opportunity to selectively kill CIN cells, we used the literature [38, 40] as well as gene expression analysis of multiple cell lines from the Cancer Cell Line Encyclopedia (CCLE) database (http://www.broadinstitute.org/ccle/home) to identify multiple non-isogenic pairs of cell lines across different tumor types, such that one cell line naturally overexpressing PLK1 could be compared to one that does not (Supplementary Figure S2B). The gene discussed is PLK1; the disease is cervical squamous intraepithelial neoplasia.